A genome-wide association study identifies protein quantitative trait loci (pQTLs)
There is considerable evidence that human genetic variation influences gene expression.
Genome-wide studies have revealed that mRNA levels are associated with genetic variation …
Genome-wide studies have revealed that mRNA levels are associated with genetic variation …
Comparative analysis of proteome and transcriptome variation in mouse
The relationships between the levels of transcripts and the levels of the proteins they encode
have not been examined comprehensively in mammals, although previous work in plants …
have not been examined comprehensively in mammals, although previous work in plants …
Identification of cis-regulatory variation influencing protein abundance levels in human plasma
Proteins are central to almost all cellular processes, and dysregulation of expression and
function is associated with a range of disorders. A number of studies in human have recently …
function is associated with a range of disorders. A number of studies in human have recently …
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
It is known that genetic variants can affect gene expression, but it is not yet completely clear
through what mechanisms genetic variation mediate this expression. We therefore …
through what mechanisms genetic variation mediate this expression. We therefore …
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
Improved understanding of genetic regulation of the proteome can facilitate identification of
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
JK Pickrell - The American Journal of Human Genetics, 2014 - cell.com
Annotations of gene structures and regulatory elements can inform genome-wide
association studies (GWASs). However, choosing the relevant annotations for interpreting …
association studies (GWASs). However, choosing the relevant annotations for interpreting …
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
Although genome-wide association studies (GWAS) of complex traits have yielded more
reproducible associations than had been discovered using any other approach, the loci …
reproducible associations than had been discovered using any other approach, the loci …
Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
Identification of protein quantitative trait loci (pQTL) helps understand the underlying
mechanisms of diseases and discover promising targets for pharmacological intervention …
mechanisms of diseases and discover promising targets for pharmacological intervention …
Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
Identifying genetic variants associated with circulating protein concentrations (protein
quantitative trait loci; pQTLs) and integrating them with variants from genome-wide …
quantitative trait loci; pQTLs) and integrating them with variants from genome-wide …
Heritability and tissue specificity of expression quantitative trait loci
Variation in gene expression is heritable and has been mapped to the genome in humans
and model organisms as expression quantitative trait loci (eQTLs). We applied integrated …
and model organisms as expression quantitative trait loci (eQTLs). We applied integrated …