Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent,
useful in the treatment of several cancers, but with several side effects such as …

Cisplatin is one of the most active cytotoxic agents in the treatment of cancer but its clinical
use is associated with nephrotoxicity. Several studies suggest that supplementation with …

This study was designed to investigate the cisplatin-induced alteration in renal antioxidant
system and the nephroprotection with ebselen. Male Wistar rats were injected with (1) …

This study aims to elucidate the molecular mechanism (s) of cisplatin nephrotoxicity and the
possible protective effects of antioxidant food supplementation on this toxicity. Twenty eight …

Cisplatin-induced nephrotoxicity is associated with an increase in lipid peroxidation and
oxygen free radicals in rat kidneys. In this study, the effects of desferrioxamine were …

Cisplatin (CDDP), an anticancer drug, induces remarkable toxicity in the kidneys of animals
and humans and it has been well documented that reactive oxygen species and the renal …

Abstract Objective: Cisplatin (DDP, cis-diamminedichloroplatinium II) is one of the most
potent chemotherapeutic antitumor drugs, but is able to generate reactive oxygen species …

Cisplatin is one of the most active cytotoxic agents used in the treatment of cancer. However,
cisplatin therapy is also associated with severe side effects like nephrotoxicity and …

The widely used anti-cancer drug cisplatin imparts various toxic manifestations in the host,
with nephrotoxicity being the most severe one. The trace element selenium shows …

The present study was aimed to investigate the ability of quercetin (QE) to ameliorate
adverse effects of cisplatin (Cis.) on the renal tissue antioxidants by investigating the kidney …