Background Aging, a complex and profound journey, leads us through a labyrinth of
physiological and pathological transformations, rendering us increasingly susceptible to …

Aging is a key independent risk factor of various vascular diseases, for which the regulatory
mechanisms remain largely unknown. Bromodomain-containing protein 4 (BRD4) is a …

Bromodomain and extraterminal domain protein 2 (BRD2), a member of the bromodomain
and extraterminal domain (BET) protein family, is a crucial epigenetic regulator with …

Oncogene-induced senescence (OIS) is a cellular defense mechanism against excessive
mitogenic signaling and tumorigenesis. One of the major pathways required for OIS is the …

Epigenetic regulation plays substantial roles in human pathophysiology, which provides
opportunities for intervention in human disorders through the targeting of epigenetic …

Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted
inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In …

Small molecules targeting bromodomains of BET proteins possess strong anti-tumor
activities and have emerged as potential therapeutics for cancer. However, the underlying …

Abstract Bromodomain‐containing protein 4 (BRD4) is overexpressed and functionally
implicated in various myeloid malignancies. However, the role of BRD4 in normal …

Aging is closely associated with atherosclerosis. Macrophages accumulate in
atherosclerotic lesions contributing to the development and progression of atherosclerosis …

Bromodomain is a conserved structural module found in many chromatin-associated
proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain …