Generation and phenotypic characterization of a galanin overexpressing mouse
K Holmberg, E Kuteeva, P Brumovsky, U Kahl… - Neuroscience, 2005 - Elsevier
In most parts of the peripheral nervous system galanin is expressed at very low levels. To
further understand the functional role of galanin, a mouse overexpressing galanin under the …
further understand the functional role of galanin, a mouse overexpressing galanin under the …
Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury
K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury
FE Holmes, SA Mahoney, D Wynick - Neuropeptides, 2005 - Elsevier
The neuropeptide galanin is present at high levels within the dorsal root ganglia (DRG) and
spinal cord during development and after peripheral nerve damage in the adult. This pattern …
spinal cord during development and after peripheral nerve damage in the adult. This pattern …
Transgenic over-expression of galanin in injured primary sensory neurons
A Bacon, FE Holmes, CJ Small, M Ghatei… - …, 2002 - journals.lww.com
The 29 amino acid neuropeptide galanin is normally expressed in< 5% of sensory neurons
in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the …
in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the …
Galanin expression in adult human dorsal root ganglion neurons: initial observations
Human dorsal root ganglia (DRGs) were obtained during various procedures and processed
for single and double in situ hybridisation using oligonucleotide probes complementary to …
for single and double in situ hybridisation using oligonucleotide probes complementary to …
Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
Galanin is a 29‐amino‐acid peptide expressed in dorsal root ganglion (DRG) neurones and
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
The role of galanin as a multi-functional neuropeptide in the nervous system
D Wynick, SWN Thompson, SB McMahon - Current opinion in …, 2001 - Elsevier
The neuropeptide galanin is expressed developmentally in the DRG and is rapidly up-
regulated 120-fold after peripheral nerve section in the adult. The generation and study of …
regulated 120-fold after peripheral nerve section in the adult. The generation and study of …
Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse—possible implications for pain processing
P Brumovsky, K Hygge-Blakeman, MJ Villar… - Journal of Chemical …, 2006 - Elsevier
The distribution of galanin was studied in the lumbar 5 dorsal root ganglia (DRGs) and
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
Central and peripheral expression of galanin in response to inflammation
RR Ji, X Zhang, Q Zhang, Å Dagerlind, S Nilsson… - Neuroscience, 1995 - Elsevier
Using in situ hybridization, immunohistochemistry and receptor binding methodology, the
galanin messenger RNA levels, galanin binding and galanin-like immunoreactivity were …
galanin messenger RNA levels, galanin binding and galanin-like immunoreactivity were …
Galanin overexpressing transgenic mice
JN Crawley, EJ Mufson, JG Hohmann, D Teklemichael… - Neuropeptides, 2002 - Elsevier
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different
promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and …
promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and …