Collagen bundle orientation (CBO) in myocardial infarct scars plays a major role in scar
mechanics and complications after infarction. We aim to compare four histopathological …

We aimed to characterize the organization of collagen within a fibrotic scar in swine and
human samples from patients with chronic infarctions. Swine were subjected to occlusion of …

Although large collagen fibers in myocardial infarct scar are highly organized, little is known
about mechanisms controlling this organization. The preexisting extracellular matrix may act …

During healing after myocardial infarction, scar collagen content and stiffness do not
correlate. We studied regional mechanics and both area fraction and orientation of large …

Collagen plays a major role in the structural organization of the heart and therefore direct
visualization of collagen fibers is a crucial component of cardiac analysis. Although linearly …

Fibrous tissue appears as echo dense areas on conventional ultrasound images; however,
the determinants of such echo brightness have not been assessed. We demonstrated …

The mechanical properties of the healing scar are an important determinant of heart function
following myocardial infarction. Yet the relationship between scar structure, scar mechanics …

To better understand the healing process after permanent coronary artery occlusion in a
canine model, the authors used polarized light microscopy. At 6 weeks after occlusion the …

The histologic examination and planimetric evaluation of tissue slices has been so far the
only available technique for studying the extent of experimental myocardial infarcts in long …

The aim of this study was to reveal the temporal and spatial changes of strain parameters
during the progression of chronic coronary ischemia. Fourteen pigs received occluder …