Type I IFNs are known to inhibit viral replication and mediate protection against viral
infection. However, recent studies revealed that these cytokines play a broader and more …

The unexpected discovery of a novel family of antiviral mediators, type III IFNs or IFN-λs,
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …

IFNs protect from virus infection by inducing an antiviral state and by modulating the immune
response. Using mice deficient in multiple aspects of IFN signaling, we found that type I and …

IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …

Defense against bacterial infections requires activation of the immune response as well as
timely reestablishment of tissue and immune homeostasis. Instauration of homeostasis is …

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the
induction of a potent antiviral gene program essential for host defense against viruses. They …

The innate immune system possesses a multitude of pathways to sense and respond to
microbial pathogens. One such family are the interferons (IFNs), a family of cytokines that …

Type I interferon (IFN), as its name implies,'interferes' with virus replication by activating
numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of …

Following virus infections, type I interferons are synthesized to induce the expression of
antiviral molecules and interfere with virus replication. The importance of early antiviral type I …

Although type I interferons (IFN-I) were initially defined as potent antiviral agents, they can
also cause decreased host resistance to some bacterial and viral infections. The many …