Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite
cells, these normally quiescent cells are induced to proliferate by wound-derived signals …

Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending
on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably …

Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

Muscle regeneration depends on a robust albeit transient inflammatory response. Persistent
inflammation is a feature of age-related regenerative deficits, yet the underlying mechanisms …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking,
satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show …

Although recent advances in broad-scale gene expression analysis have dramatically
increased our knowledge of the repertoire of mRNAs present in multiple cell types, it has …

Adult skeletal muscle has a robust capacity for self-repair, owing to synergies between
muscle satellite cells and the immune system. In vitro models of muscle self-repair would …

Muscle stem cells (MuSCs, satellite cells) are the major contributor to muscle regeneration.
Like most adult stem cells, long-term expansion of MuSCs in vitro is difficult. The in vivo …

INTRODUCTION Mammalian skeletal muscle harbors tissue-specific stem cells that are
triggered to replace damaged fibers after injury. Genetic ablation of satellite cells in the …