Erythropoiesis is a complex multistep process encompassing the differentiation of
hemopoietic stem cells to mature erythrocytes. The steps involved in this complex …

Commitment of hematopoietic cells to the erythroid lineage involves the actions of several
transcription factors, including TAL1, LMO2, and GATA-2. The differentiation of committed …

Simple spirits consider mammalian erythrocytes as membrane-surrounded hemoglobin-
containing vesicles floating in circulation. Indeed, they lack organelles including nuclei and …

673 and erythropoietin nucleosomal cleavage of DNA. These changes are not accompanied
by loss of cellular energy and can be prevented by the protein synthesis inhibitor …

Eryptosis, the suicidal death of erythrocytes, is characterised by cell shrinkage, membrane
blebbing and cell membrane phospholipid scrambling with phosphatidylserine exposure at …

Erythropoietic rate is regulated at least in part through the erythropoietin receptor-mediated
survival of splenic early erythroblasts. Future research will delineate how multiple …

Highlights•Enucleation is a rate-limiting step in erythropoiesis that leads to the formation of
RBCs.•Regulators of enucleation range from transcription factors to miRNAs.•Optimum …

Primitive erythroid cells, the first red blood cells produced in the mammalian embryo, are
necessary for embryonic survival. Erythropoietin and its receptor EpoR, are absolutely …

Eryptosis is a regulated cell death (RCD) of mature erythrocytes initially described as a
counterpart of apoptosis for enucleated cells. However, over the recent years, a growing …

Eryptosis, the suicidal death of erythrocytes, is characterized by erythrocyte shrinkage,
blebbing, and phospholipid scrambling of the cell membrane. Eryptosis is triggered by …