[PDF][PDF] Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …
differences lies in the sex chromosomes. Although the functions of the X chromosome …
RNA helicase-dependent gene looping impacts messenger RNA processing
S Terrone, J Valat, N Fontrodona, G Giraud… - Nucleic Acids …, 2022 - academic.oup.com
Abstract DDX5 and DDX17 are DEAD-box RNA helicase paralogs which regulate several
aspects of gene expression, especially transcription and splicing, through incompletely …
aspects of gene expression, especially transcription and splicing, through incompletely …
[PDF][PDF] The RNA helicase DDX6 controls cellular plasticity by modulating P-body homeostasis
Post-transcriptional mechanisms have the potential to influence complex changes in gene
expression, yet their role in cell fate transitions remains largely unexplored. Here, we show …
expression, yet their role in cell fate transitions remains largely unexplored. Here, we show …
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
H Song, X Ji - Nature communications, 2019 - nature.com
DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short
double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains …
double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains …
DDX3X and DDX3Y are redundant in protein synthesis
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X-and
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …
[HTML][HTML] Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation
G Giraud, S Terrone, CF Bourgeois - BMB reports, 2018 - ncbi.nlm.nih.gov
Abstract RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene
expression in different biological contexts through diverse activities. Special attention has …
expression in different biological contexts through diverse activities. Special attention has …
G-quadruplex structures trigger RNA phase separation
Liquid–liquid phase separation plays an important role in a variety of cellular processes,
including the formation of membrane-less organelles, the cytoskeleton, signalling …
including the formation of membrane-less organelles, the cytoskeleton, signalling …
Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish
Vertebrate embryogenesis involves a conserved and fundamental process, called the
maternal-to-zygotic transition (MZT), which marks the switch from a maternal factors …
maternal-to-zygotic transition (MZT), which marks the switch from a maternal factors …
[PDF][PDF] Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation
Glucose is a universal bioenergy source; however, its role in controlling protein interactions
is unappreciated, as are its actions during differentiation-associated intracellular glucose …
is unappreciated, as are its actions during differentiation-associated intracellular glucose …
[PDF][PDF] Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis
C Gong, JA Krupka, J Gao, NF Grigoropoulos… - Molecular cell, 2021 - cell.com
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA
biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for …
biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for …