Complement deficiencies comprise between 1 and 10% of all primary immunodeficiencies
(PIDs) according to national and supranational registries. They are still considered rare and …

This guideline aims to describe the complement system and the functions of the constituent
pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

The complement system is crucial for defense against pathogens and the removal of dying
cells or immune complexes. Thus, clinical indications for possible complete complement …

Complement deficiencies are probably vastly under-diagnosed within clinical medicine.
Judging from a Swedish study of C2 deficiency, a deficiency with an estimated prevalence of …

Summary OTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW
SERIES ON COMPLEMENT FACTOR H Genetics and disease associations of human …

In the past 20 years, we have witnessed tremendous advances in our ability to diagnose and
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …

Complement deficient cases reported in the second half of the last century have been of
great help in defining the role of complement in host defence. Surveys of the deficient …

Aberrations in the complement system have been shown to be direct or indirect
pathophysiological mechanisms in a number of diseases and pathological conditions such …

Introduction Complement immunodeficiencies (excluding hereditary angioedema and
mannose binding lectin deficiency) are rare. Published literature consists largely of case …