Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models

HY Kim, HK Min, HW Song, A Yoo, S Lee, KP Kim… - Drug Delivery, 2022 - Taylor & Francis
Exosomes are nanosized extracellular vesicles secreted by various cell types, including
those of the immune system, such as natural killer (NK) cells. They play a role in intercellular …

[HTML][HTML] NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions

H Luo, Y Zhou, J Zhang, Y Zhang, S Long… - Frontiers in …, 2023 - frontiersin.org
Exosomes are membranous vesicles actively secreted by almost all cells and they deliver
certain intracellular molecules, including nucleic acids, proteins, and lipids, to target cells …

[HTML][HTML] Canine natural killer cell-derived exosomes exhibit antitumor activity in a mouse model of canine mammary tumor

J Lee, SA Lee, NY Gu, SY Jeong, JS Byeon… - BioMed Research …, 2021 - hindawi.com
Natural killer (NK) cells are key immune cells engaged in fighting infection and malignant
transformation. In this study, we found that canine NK cell-derived exosomes (NK …

Novel alternatives to extracellular vesicle-based immunotherapy–exosome mimetics derived from natural killer cells

L Zhu, P Gangadaran, S Kalimuthu, JM Oh… - Artificial cells …, 2018 - Taylor & Francis
Exosomes are endogenous nanocarriers that can deliver biological information between
cells. They are secreted by all cell types, including immune cells such as natural killer (NK) …

[HTML][HTML] Exosomes derived from natural killer cells exert therapeutic effect in melanoma

L Zhu, S Kalimuthu, P Gangadaran, JM Oh, HW Lee… - Theranostics, 2017 - ncbi.nlm.nih.gov
Objective: Exosomes are nanovesicles that are released from normal and tumor cells and
are detectable in cell culture supernatant and human biological fluids. Although previous …

[HTML][HTML] Targeting and therapy of glioblastoma in a mouse model using exosomes derived from natural killer cells

L Zhu, JM Oh, P Gangadaran, S Kalimuthu… - Frontiers in …, 2018 - ncbi.nlm.nih.gov
Objective Glioblastoma is a highly aggressive primary brain tumor that is resistant to
radiotherapy and chemotherapy. Natural killer (NK) cells have been used to treat incurable …

[HTML][HTML] Hypoxia enhances the production and antitumor effect of exosomes derived from natural killer cells

Y Jiang, H Jiang, K Wang, C Liu, X Man… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Exosomes are a subgroup of extracellular vesicles that are naturally released
by almost all types of cells. However, the factors that promote the capacity of natural killer …

Bifacial effects of engineering tumour cell-derived exosomes on human natural killer cells

Q Li, Q Huang, T Huyan, Y Wang, Q Huang… - Experimental Cell …, 2018 - Elsevier
Extracellular vesicles (EVs) are nano vesicular structures that are secreted by almost all
kinds of cells. Exosomes are small EVs derived from endosomes, with a diameter between …

NK cell-released exosomes: natural nanobullets against tumors

S Fais - Oncoimmunology, 2013 - Taylor & Francis
We have recently reported that human natural killer (NK) cells release exosomes that
express both NK-cell markers and cytotoxic molecules. Similar results were obtained with …

Immune surveillance properties of human NK cell-derived exosomes

L Lugini, S Cecchetti, V Huber, F Luciani… - The Journal of …, 2012 - journals.aai.org
Exosomes are nanovesicles released by normal and tumor cells, which are detectable in
cell culture supernatant and human biological fluids, such as plasma. Functions of …