Objective This review summarizes a portion of the discussions of an NIH Workshop
(Bethesda, MD, 2015) titled “Self‐Regulation of Appetite—It's Complicated,” which focused …

Food intake (eating) is a form of behavior that is subject to conscious control. In practice,
many obese and weight‐gaining individuals claim that their eating is out of (their) control …

There is an asymmetry in the operation of physiological processes that maintain body
weight. The body exerts a strong defence against undernutrition and weight loss, but applies …

Perspective on the Central Control of Appetite Page 1 Perspective on the Central Control of
Appetite John E. Blundell Abstract BLUNDELL, JOHN E. Perspective on the central control of …

Context Energy balance is critical for survival and health, and control of food intake is an
integral part of this process. This report reviews hormonal signals that influence food intake …

The prevailing model of homeostatic appetite control envisages two major inputs; signals
from adipose tissue and from peptide hormones in the gastrointestinal tract. This model is …

The recent increase in the worldwide prevalence of obesity has understandably focused
attention on the environmental determinants of this epidemic. Whereas identifying the …

Knowledge of the regulation of food intake is crucial to an understanding of body weight and
obesity. Traditionally, food intake has been researched within the homeostatic approach to …

A changing environment and lifestyle on the background of evolutionary engraved and
perinatally imprinted physiological response patterns is the foremost explanation for the …

For obese individuals, successful weight loss and maintenance are notoriously difficult.
Traditional drug development fails to exploit knowledge of the psychological factors that …