Background Tolerating higher partial pressure of carbon dioxide (pCO 2) in mechanically
ventilated, extremely low birthweight infants might reduce ventilator-induced lung injury and …

Lung injury in ventilated premature infants occurs primarily through the mechanism of
volutrauma, often due to the combination of high tidal volumes in association with a high end …

Background Experimental animal data and uncontrolled, observational studies in human
infants have suggested that hyperventilation and hypocapnia may be associated with …

Permissive hypercapnia appears as a safe and effective management strategy to decrease
morbidity from bronchopulmonary dysplasia in premature infants. Although the preliminary …

Although lifesaving, mechanical ventilation can result in lung injury and contribute to the
development of bronchopulmonary dysplasia. The most critical determinants of lung injury …

There is no consensus on the optimal pCO2 levels in the newborn. We reviewed the effects
of hypercapnia and hypocapnia and existing carbon dioxide thresholds in neonates. A …

Background Tolerating higher partial pressures of carbon dioxide (PCO2) in mechanically
ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may …

Abstract Background: Ventilation with higher PaCO2 goals may reduce lung injury and
bronchopulmonary dysplasia (BPD). The effect may be enhanced by using a higher PaCO2 …

Advances in neonatology have resulted in an increase in the absolute number of survivors
with chronic lung disease (CLD), though its overall incidence has not changed. Though the …

Importance A sustained inflation (SI) provided at birth might reduce bronchopulmonary
dysplasia (BPD). Objective This study aims to examine whether an SI-guided exhaled …