The p53‐inducible TIGAR protein functions as a fructose‐2, 6‐bisphosphatase, promoting
the pentose phosphate pathway and helping to lower intracellular reactive oxygen species …

The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator)
functions as a fructose-2, 6-bisphosphatase (Fru-2, 6-BPase), and through promotion of the …

The p53 tumor-suppressor protein prevents cancer development through various
mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of …

Cancers cells shift their metabolism towards glycolysis in order to help them support the
biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and …

The p53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis, resulting in
higher intracellular NADPH, lower reactive oxygen species (ROS) and autophagy activity. In …

TIGAR (TP53-induced glycolysis and apoptosis regulator) is the downstream target gene of
p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6 …

The tumor suppressor gene Tp53 encodes p53, a pivotal transcription factor with a broad
target gene repertoire. Induction and stabilization of p53 during DNA damage and oncogene …

Altered metabolism in tumor cells is increasingly recognized as a core component of the
neoplastic phenotype. Because p53 has emerged as a master metabolic regulator, we …

Regulation of metabolic pathways plays an important role in controlling cell growth,
proliferation, and survival. TIGAR acts as a fructose-2, 6-bisphosphatase, potentially …

The sirtuin family of class III histone deacetylases has been extensively implicated in
modulating a myriad of cellular processes, including energy metabolism, stress response …