The symptoms of ageing are somewhat different and can lead to the altered role of the
cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems …

Aging hallmarks include decreased progenitor cell functions. The Wnt/β-catenin signaling
pathway has emerged as a key player in cellular aging in recent years. Wnt activity changes …

The molecular pathophysiology of heart failure, which is one of the leading causes of
mortality, is not yet fully understood. Heart failure can be regarded as a systemic syndrome …

Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart
disease. However, how RAS activation causes cardiac lesions remains elusive. Here we …

In heart failure (HF) caused by hypertension, the myocyte size increases, and the cardiac
wall thickens. A low-molecular-weight compound called ICG001 impedes β-catenin …

Calcium dysregulation and mitochondrial dysfunction are key elements in the development
of sepsis-induced cardiac dysfunction. Evidences have suggested that inhibition of Wnt/β …

Many factors and molecular pathways are involved in the pathogenesis of arterial
hypertension. The increase in blood pressure may be determined by the properties of …

Aging is associated with various heart diseases, and this may be attributable, in part, to the
prolonged exposure of the heart to cardiovascular risk factors. However, aging is also …

Vascular calcification (VC) is a pathological process underpinning major cardiovascular
conditions and has attracted public attention due to its high morbidity and mortality. Chronic …

The renin-angiotensin system (RAS) regulates diverse cellular responses and is crucial for
normal organ development and function. On the other hand, RAS exerts deleterious effects …