Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

BS Karam, A Chavez-Moreno, W Koh, JG Akar… - Cardiovascular …, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …

Diabetes mellitus and atrial fibrillation: pathophysiological mechanisms and potential upstream therapies

CA Goudis, P Korantzopoulos, IV Ntalas… - International journal of …, 2015 - Elsevier
Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation
(AF) while AF is a strong and independent marker of overall mortality and cardiovascular …

The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights

LJ Bohne, D Johnson, RA Rose, SB Wilton… - Frontiers in …, 2019 - frontiersin.org
A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk
factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age …

Diabetes mellitus and atrial remodeling: mechanisms and potential upstream therapies

Q Zhang, T Liu, CY Ng, G Li - Cardiovascular therapeutics, 2014 - Wiley Online Library
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice, and its
prevalence has increasing substantially over the last decades. Recent data suggest that …

Atrial cardiomyopathy: pathophysiology and clinical consequences

A Goette, U Lendeckel - Cells, 2021 - mdpi.com
Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an
annual increase of 5 million cases. Most AF patients have an established form of an atrial …

Oxidant and inflammatory mechanisms and targeted therapy in atrial fibrillation: an update

A Gutierrez, DR Van Wagoner - Journal of cardiovascular …, 2015 - journals.lww.com
Atrial fibrillation (AF) is an important cause of stroke and risk factor for heart failure and
death. Current pharmacologic treatments for AF have limited efficacy, and treatments that …

Atrial fibrillation: effects beyond the atrium?

RS Wijesurendra, B Casadei - Cardiovascular research, 2015 - academic.oup.com
Atrial fibrillation (AF) is the most common sustained clinical arrhythmia and is associated
with significant morbidity, mostly secondary to heart failure and stroke, and an estimated two …

Atrial Fibrillation and Diabetes Mellitus: JACC Review Topic of the Week

A Wang, JB Green, JL Halperin, JP Piccini - Journal of the American …, 2019 - jacc.org
Diabetes mellitus is one of the most common chronic medical conditions, and is a risk factor
for the development of atrial fibrillation (AF). The presence of diabetes in patients with AF is …

Implications of inflammation and fibrosis in atrial fibrillation pathophysiology

M Harada, S Nattel - Cardiac Electrophysiology Clinics, 2021 - cardiacep.theclinics.com
Inflammation has been implicated in the pathophysiology of atrial fibrillation (AF) and
mediates various pathologic processes such as oxidative stress and apoptosis. Atrial fibrosis …

Role of inflammatory signaling in atrial fibrillation

L Scott Jr, N Li, D Dobrev - International journal of cardiology, 2019 - Elsevier
Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced
inflammatory response. Emerging evidence points to a causal role of inflammatory signaling …