Controlling receptor functional selectivity profiles for opioid receptors is a promising
approach for discovering safer analgesics; however, the structural determinants conferring …

Clinical treatment of acute to severe pain relies on the use of opioids. While their potency is
significant, there are considerable side effects that can negatively affect patients. Their rise …

Opioids, and more specifically μ-opioid receptor (MOR) agonists such as morphine, have
long been clinically used as therapeutics for severe pain states but often come with serious …

Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain,
though they represent the second line of treatment behind GABA analogs, antidepressants …

Biased agonists, which selectively stimulate certain signaling pathways controlled by a G
protein-coupled receptor (GPCR), hold great promise as drugs that maximize efficacy while …

Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …

Achieving effective pain management is one of the major challenges associated with
modern day medicine. Opioids, such as morphine, have been the reference treatment for …

Biased agonism refers to the ability of compounds to drive preferred signaling pathways and
avoid adverse signaling pathways in a ligand-dependent manner for some G-protein …

Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but
are also associated with fatal respiratory depression through a pathway that remains …

Opioids such as morphine and oxycodone are analgesics frequently prescribed for the
treatment of moderate or severe pain. Unfortunately, these medications are associated with …