Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X
chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST silencing, causing …

X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of
gene expression, wherein the long non-coding RNA XIST spreads across the X …

Female human pluripotent stem cells (hPSCs) regularly show erosion of X chromosome
inactivation featured by the loss of the long non-coding (lnc) RNA XIST and the …

Although the reactivation of silenced X chromosomes has been observed as part of the
process of reprogramming female somatic cells into induced pluripotent stem cells (iPSCs) …

Female human pluripotent stem cells (PSCs) have variable X-chromosome inactivation
(XCI) status. One of the X chromosomes may either be inactive (Xi) or display some active …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

Human pluripotent stem cells (hPSCs) have proven to be valuable tools for both drug
discovery and the development of cell-based therapies. However, the long non-coding RNA …

Dosage compensation of sex-chromosome gene expression between male and female
mammals is achieved via X chromosome inactivation (XCI) by employing epigenetic …

Reprogramming somatic cells to derive induced pluripotent stem cells (iPSCs) has provided
a new method to model disease and holds great promise for regenerative medicine …

Human pluripotent stem cells (hPSCs) display extensive epigenetic instability, particularly
on the X chromosome. In this study, we show that, in hPSCs, the inactive X chromosome has …