The N-methyl-d-aspartate (NMDA) receptor, an ionotropic glutamate receptor, may play a
significant role in the development and maintenance of an inflammatory pain. Activation of …

The involvement of NMDA receptors in rats with peripheral inflammation and hyperalgesia
was evaluated by administration of the non-competitive NMDA receptor antagonist, MK-801 …

Nitric oxide modulates pain development. However, there is no evidence on the effect of
nitroxyl (HNO/NO−) in nociception. Therefore, we addressed whether nitroxyl inhibits …

In the rat, loose ligation of the sciatic nerve results in behavioural signs of hyperalgesia
reminiscent of neuropathy in man. A further rat model, of chronic inflammatory hyperalgesia …

Ketamine, an NMDA receptor antagonist, has been approved to have analgesic effects. It is
known that nitric oxide pathway is involved in antinociception but with dual effects. In this …

Previously we described the antinociceptive effect of magnesium sulfate and dizocilpine (MK-
801) in the visceral and somatic rat models of pain. In the somatic model of pain, we …

The effect of inhibition of nitric oxide synthase (NOS) on hindpaw hyperalgesia (assessed
using mechanical and thermal noxious stimuli) and oedema formation following intraplantar …

The effects of N-methyl-d-aspartate (NMDA) receptor antagonists on mechanical
hyperalgesia associated with tissue inflammation were studied. Following an injection of the …

Using NADPH-d histochemistry, the effect of NMDA receptor antagonist MK-801 on the
expression of nitric oxide synthase (NOS) in the dorsal horn of the spinal cord was …

Clinical reports have described a long-lasting relief in neuropathic pain patients treated with
NMDA receptor antagonists; it is unclear, however, what mediates this effect. In this work, we …