The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic
demand. This broad concept has been propagated to explain insulin resistance and …

Human physiology needs to be well adapted to cope with major discontinuities in both the
supply of and demand for energy. This adaptability requires 'a clear capacity to utilize lipid …

Glucose, fatty acids, and amino acids among others are oxidized to generate adenosine
triphosphate (ATP). These fuels are supplied from the environment (through food intake) and …

Metabolic flexibility is defined as the ability to adapt substrate oxidation rates in response to
changes in fuel availability. The inability to switch between the oxidation of lipid and …

Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation,
as the mitochondrial machinery responsible for carbon combustion switches freely between …

Energy homeostasis is critical for the survival of species. Therefore, multiple and complex
mechanisms have evolved to regulate energy intake and expenditure to maintain body …

Metabolic adaptation to a disturbance of homeostasis is determined by a series of
interconnected physiological processes and molecular mechanisms that can be followed in …

Metabolic inflexibility is defined as an impaired capacity to switch between different energy
substrates and is a hallmark of insulin resistance and type 2 diabetes mellitus (T2 DM) …

Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability.
The inability to modify fuel oxidation in response to changes in nutrient availability has been …