Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not
amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non …

The GTP-binding protein RhoA regulates microfilament dynamics in many cell types and
mediates the inhibition of axonal regeneration by myelin and chondroitin sulfate …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively used to relieve pain and
inflammation in humans via cyclooxygenase inhibition. Our recent research suggests that …

Increasing evidence points to a role for spinal neuroimmune dysregulation (glial cell
activation and cytokine expression) in the pathogenesis of chronic pain. Suppression of …

This study was undertaken as part of the NIH “Facilities of Research Excellence-Spinal Cord
Injury” project to support independent replication of published studies. Here, we repeat key …

Traumatic brain injury (TBI) can induce progressive neurodegeneration in association with
chronic inflammation. Since chronic treatment with the non-steroidal anti-inflammatory drug …

Ibuprofen is a nonsteroidal anti-inflammatory drug widely used to relieve pain and
inflammation in many disorders via inhibition of cyclooxygenases. Recently, we have …

Glucocorticoids have been used to treat neuropathic pain for many years, but the underlying
mechanisms are still unknown. Recent studies indicate that pathological pain states may be …

Inflammatory mechanisms have been suggested to be involved in the basic
pathophysiologic events leading to nerve root injury after local application of nucleus …

Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most
commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase …