Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …

Relentless, repetitive itching and scratching is a debilitating feature of many chronic
inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch …

The ability to sense the environment is essential to survival and is the primary purpose of the
somatosensory nervous system. However, despite its highly conserved nature, the sensation …

Itch is described as an irritating sensation that triggers a desire to scratch. However, this
definition hardly seems fitting for the millions of people who suffer from intractable itch …

Itch and pain are closely related but distinct sensations. They share largely overlapping
mediators and receptors, and itch-responding neurons are also sensitive to pain stimuli. Itch …

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic
persistent itching can be devastating. Despite the clinical importance of the itch sensation, its …

Lightly stroking the lips or gently poking some skin regions can evoke mechanical itch in
healthy human subjects. Sensitization of mechanical itch and persistent spontaneous itch …

Itch is a unique sensation that helps organisms scratch away external threats; scratching
itself induces an immune response that can contribute to more itchiness. Itch is induced …