Whole body exercise tolerance is the consummate example of integrative physiological
function among the metabolic, neuromuscular, cardiovascular, and respiratory systems …

Growing evidence has demonstrated exercise as an effective way to promote cardiovascular
health and protect against cardiovascular diseases However, the underlying mechanisms of …

Cardiovascular disease (CVD) is a major global cause of mortality, which has prompted
numerous studies seeking to reduce the risk of heart failure and sudden cardiac death …

Exercise provides one of the most severe, yet physiological, stresses to the intact
cardiovascular system and is a major determinant of the utilization of metabolic substrates …

Exercise and physical activity function as a patho-physiological process that can prevent,
manage, and regulate numerous chronic conditions, including metabolic syndrome and age …

The benefit of regular physical activity and exercise training for the prevention of
cardiovascular and metabolic diseases is undisputed. Many molecular mechanisms …

Valid and reliable experimental models are essential to gain insight into the cellular and
molecular mechanisms underlying the beneficial effects of exercise in prevention, treatment …

Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

Functional assessments of cardiovascular fitness (CVF) are needed to establish animal
models of dysfunction, test the effects of novel therapeutics, and establish the cardio …

The association between low exercise capacity and all-cause morbidity and mortality is
statistically strong yet mechanistically unresolved. By connecting clinical observation with a …