[HTML][HTML] Genomic and epigenomic profiling of high-risk intestinal metaplasia reveals molecular determinants of progression to gastric cancer
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. We performed (epi) genomic profiling of 138 IMs from …
increased gastric cancer (GC) risk. We performed (epi) genomic profiling of 138 IMs from …
[HTML][HTML] Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
[HTML][HTML] Role of p53 in the progression of gastric cancer
RA Busuttil, GV Zapparoli, S Haupt, C Fennell… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer (GC) but is
poorly described in terms of molecular changes. Here, we explored the role of TP53, a …
poorly described in terms of molecular changes. Here, we explored the role of TP53, a …
Single-cell RNA sequencing unifies developmental programs of esophageal and gastric intestinal metaplasia
K Nowicki-Osuch, L Zhuang, TS Cheung, EL Black… - Cancer discovery, 2023 - AACR
Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …
AGA technical review on gastric intestinal metaplasia—natural history and clinical outcomes
Gastric cancer is the third leading cause of cancer-related mortality and the fifth most
common cancer globally. An estimated 1 million new cases and 750,000 related deaths are …
common cancer globally. An estimated 1 million new cases and 750,000 related deaths are …
Histologic subtyping of gastric intestinal metaplasia: overview and considerations for clinical practice
SC Shah, AJ Gawron, RA Mustafa… - Gastroenterology, 2020 - gastrojournal.org
Gastric cancer remains the third leading cause of cancer-related mortality and the fifth most
common cancer worldwide, responsible for an estimated 1 million new cases and more than …
common cancer worldwide, responsible for an estimated 1 million new cases and more than …
DNA methylation and genetic aberrations in gastric cancer
G Usui, K Matsusaka, Y Mano, M Urabe, S Funata… - Digestion, 1964 - karger.com
Background: Gastric cancer (GC) is one of the leading causes of cancer-related deaths
worldwide. GC is a pathologically and molecularly heterogeneous disease. DNA …
worldwide. GC is a pathologically and molecularly heterogeneous disease. DNA …
[HTML][HTML] Overview of current concepts in gastric intestinal metaplasia and gastric cancer
DS Jencks, JD Adam, ML Borum, JM Koh… - Gastroenterology & …, 2018 - ncbi.nlm.nih.gov
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with
intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The …
intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The …
Oral and gastric microbiome in relation to gastric intestinal metaplasia
Evidence suggests that Helicobacter pylori plays a role in gastric cancer (GC) initiation.
However, epidemiologic studies on the specific role of other bacteria in the development of …
However, epidemiologic studies on the specific role of other bacteria in the development of …
AGA technical review on gastric intestinal metaplasia—epidemiology and risk factors
Gastric cancer remains the third leading cause of cancer-related mortality and the fifth most
common cancer worldwide. 1 There is marked global variation of disease with areas of high …
common cancer worldwide. 1 There is marked global variation of disease with areas of high …
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