[HTML][HTML] Genomic and epigenomic profiling of high-risk intestinal metaplasia reveals molecular determinants of progression to gastric cancer

KK Huang, K Ramnarayanan, F Zhu, S Srivastava… - Cancer cell, 2018 - cell.com
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. We performed (epi) genomic profiling of 138 IMs from …

[HTML][HTML] Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression

KK Huang, H Ma, RHH Chong, T Uchihara, BSX Lian… - Cancer Cell, 2023 - cell.com
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …

[HTML][HTML] Role of p53 in the progression of gastric cancer

RA Busuttil, GV Zapparoli, S Haupt, C Fennell… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer (GC) but is
poorly described in terms of molecular changes. Here, we explored the role of TP53, a …

Single-cell RNA sequencing unifies developmental programs of esophageal and gastric intestinal metaplasia

K Nowicki-Osuch, L Zhuang, TS Cheung, EL Black… - Cancer discovery, 2023 - AACR
Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …

AGA technical review on gastric intestinal metaplasia—natural history and clinical outcomes

AJ Gawron, SC Shah, O Altayar, P Davitkov… - …, 2020 - gastrojournal.org
Gastric cancer is the third leading cause of cancer-related mortality and the fifth most
common cancer globally. An estimated 1 million new cases and 750,000 related deaths are …

Histologic subtyping of gastric intestinal metaplasia: overview and considerations for clinical practice

SC Shah, AJ Gawron, RA Mustafa… - Gastroenterology, 2020 - gastrojournal.org
Gastric cancer remains the third leading cause of cancer-related mortality and the fifth most
common cancer worldwide, responsible for an estimated 1 million new cases and more than …

DNA methylation and genetic aberrations in gastric cancer

G Usui, K Matsusaka, Y Mano, M Urabe, S Funata… - Digestion, 1964 - karger.com
Background: Gastric cancer (GC) is one of the leading causes of cancer-related deaths
worldwide. GC is a pathologically and molecularly heterogeneous disease. DNA …

[HTML][HTML] Overview of current concepts in gastric intestinal metaplasia and gastric cancer

DS Jencks, JD Adam, ML Borum, JM Koh… - Gastroenterology & …, 2018 - ncbi.nlm.nih.gov
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with
intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The …

Oral and gastric microbiome in relation to gastric intestinal metaplasia

F Wu, L Yang, Y Hao, B Zhou, J Hu… - … journal of cancer, 2022 - Wiley Online Library
Evidence suggests that Helicobacter pylori plays a role in gastric cancer (GC) initiation.
However, epidemiologic studies on the specific role of other bacteria in the development of …

AGA technical review on gastric intestinal metaplasia—epidemiology and risk factors

O Altayar, P Davitkov, SC Shah, AJ Gawron… - …, 2020 - gastrojournal.org
Gastric cancer remains the third leading cause of cancer-related mortality and the fifth most
common cancer worldwide. 1 There is marked global variation of disease with areas of high …