[HTML][HTML] Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments
SM Khirallah, HMM Ramadan, A Shawky, SH Qahl… - Molecules, 2022 - mdpi.com
Inflammation is the main cause of several autoimmune diseases, including type I diabetes,
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …
Exploring anti-inflammatory potential of thiazolidinone derivatives of benzenesulfonamide via synthesis, molecular docking and biological evaluation
SB Bari, SD Firake - Anti-Inflammatory & Anti-Allergy Agents …, 2016 - ingentaconnect.com
Background: The present study reports the synthesis and biological evaluation of
thiazolidinone derivatives bearing benzenesulfonamide investigated for cyclooxygenase-2 …
thiazolidinone derivatives bearing benzenesulfonamide investigated for cyclooxygenase-2 …
Design, synthesis, anti-inflammatory evaluation and molecular docking of novel thiophen-2-ylmethylene-based derivatives as potential TNF-α production inhibitors
DH Dawood, ES Nossier, MF Abdelhameed… - Bioorganic …, 2022 - Elsevier
Inflammation is considered to be an alarming signal for the progress of varied biological
complications. Based on the previous reports in the literature that proved the noticeable …
complications. Based on the previous reports in the literature that proved the noticeable …
Design and synthesis of 1, 3-benzothiazinone derivatives as potential anti-inflammatory agents
J Li, X Fan, J Deng, Y Liang, S Ma, Y Lu… - Bioorganic & Medicinal …, 2020 - Elsevier
Abstract A series of 1, 3-benzothiazinone derivatives were designed and synthesized for
pharmacological assessments. Among the synthesized 19 compounds, some compounds …
pharmacological assessments. Among the synthesized 19 compounds, some compounds …
Discovery and optimization of 2, 3-diaryl-1, 3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity
Several studies have indicated the potential therapeutic outcomes of combining selective
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …
Design, Synthesis, Molecular docking, and biological evaluation of novel 2, 3-diaryl-1, 3-thiazolidine-4-one derivatives as potential anti-inflammatory and cytotoxic …
YO Mekhlef, AM AboulMagd, AM Gouda - Bioorganic Chemistry, 2023 - Elsevier
Abstract A new series of 2, 3-diaryl-1, 3thiazolidin-4-one derivatives was designed,
synthesized, and evaluated for their cytotoxicity and COXs inhibitory activities. Among these …
synthesized, and evaluated for their cytotoxicity and COXs inhibitory activities. Among these …
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2, 5-dione derivatives as multitarget anti-inflammatory agents
In recent years, drug discovery paradigm has been shifted from conventional single target
inhibition toward multitarget design concept. In current research, we have reported …
inhibition toward multitarget design concept. In current research, we have reported …
Synthesis, biological evaluation and docking study of 1, 3, 4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX
YM Omar, HHM Abdu-Allah, SG Abdel-Moty - Bioorganic chemistry, 2018 - Elsevier
Selective inhibition of both cyclooxygenase-2 (COX-2) and 15-lipooxygenase (15-LOX) may
provide good strategy for alleviation of inflammatory disorders while minimizing side effects …
provide good strategy for alleviation of inflammatory disorders while minimizing side effects …
Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1, 2-benzothiazine derivatives as novel anti-inflammatory agents
BM Szczęśniak-Sięga, B Wiatrak, Ż Czyżnikowska… - Bioorganic …, 2021 - Elsevier
Abstract Novel arylpiperazine-1, 2-benzothiazine derivatives have been designed and
synthesized as potential anti-inflammatory agents. Their structure and properties have been …
synthesized as potential anti-inflammatory agents. Their structure and properties have been …
Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2, 3, 4-trisubstituted thiophene derivatives
New series of thiophene derivatives were synthesized and evaluated for their in vivo anti-
inflammatory activity using carrageenan-induced paw edema model. The most active in vivo …
inflammatory activity using carrageenan-induced paw edema model. The most active in vivo …