Development of heterologous systems to produce useful HCV vaccine candidates is an
important part of HCV research. In this study different HCV structural region variants were …

The expression and processing of the Hepatitis C virus core protein (HCcAg) were analyzed
in the methylotrophic yeast Pichia pastoris. Two proteins with 21 (p21) and 23kDa (p23) …

Development of an effective vaccine may be the key in the control of hepatitis C virus (HCV)
infection. Recent studies have shown that HCV envelope proteins can induce broadly …

A tetracycline-regulated system was used to generate cell lines allowing tightly controlled
expression of a hepatitis C virus (HCV) cDNA comprising the 5′ noncoding, the core, and …

Processing of the envelope glycoproteins (E1 and E2) of hepatitis C virus (HCV) was
investigated by using cDNA clones covering the structural and part of the nonstructural (NS) …

Investigation of the hepatitis C virus (HCV) life cycle and the evaluation of novel antiviral
strategies are limited by the lack of an efficient cell culture system. Therefore, continuous …

A C-terminally truncated form of the hepatitis C virus (HCV) putative envelope glycoprotein
E2 was expressed in two yeast species, Saccharomyces cerevisiae and Kluyveromyces …

Experimental evidence suggests that the hepatitis C virus (HCV) core protein has several
biological properties and is implicated as a viral factor in HCV-mediated pathogenesis. In …

We cloned and expressed the sequences encoding the structural proteins of the hepatitis C
virus in a baculovirus eukaryotic expression system. Four recombinant constructs expressed …

Investigation of the hepatitis C virus (HCV) life cycle is limited by the lack of an efficient cell
culture system. Employing a tetracycline-regulated gene expression system we generated a …