Biomaterial strategies for restorative therapies in Parkinson's disease

S Mirzaei, K Kulkarni, K Zhou, PJ Crack… - ACS Chemical …, 2021 - ACS Publications
Parkinson's disease (PD) is a progressive neurological disorder, in which dopaminergic
midbrain neurons degenerate, leading to dopamine depletion that is associated with …

Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease

JP Harris, JC Burrell, LA Struzyna, HI Chen… - npj Parkinson's …, 2020 - nature.com
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disease, affecting 1–2% of people over 65. The classic motor symptoms of PD result from …

Dopaminergic neurons transplanted using cell‐instructive biomaterials alleviate Parkinsonism in rodents

MM Adil, AT Rao, GN Ramadoss… - Advanced Functional …, 2018 - Wiley Online Library
Cell replacement therapy (CRT) is a promising treatment for degenerative disorders, such as
Parkinson's disease (PD). However, CRT is in general hindered by poor graft survival …

Progress in dopaminergic cell replacement and regenerative strategies for Parkinson's disease

W Chen, Q Huang, S Ma, M Li - ACS Chemical Neuroscience, 2018 - ACS Publications
Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder
symptomatically characterized by resting tremor, rigidity, bradykinesia, and gait impairment …

Biomaterials in the treatment of Parkinson's disease

UM Krishnan - Neurochemistry International, 2021 - Elsevier
Parkinson's disease is a neurodegenerative disease, the treatment of which is mainly
centred around supplementation of dopamine. Additional targets have been identified and …

Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway

WJ Gordián-Vélez, KD Browne, JH Galarraga, JE Duda… - BioRxiv, 2021 - biorxiv.org
Parkinson's disease (PD) affects 10 million patients worldwide, making it the second most
prevalent neurodegenerative disease. Motor symptoms emerge from the loss of dopamine in …

Regenerative therapies for Parkinson's disease: An update

TB Stoker, RA Barker - BioDrugs, 2018 - Springer
Parkinson's disease is the second most common neurodegenerative disorder. It is
characterised by a typical movement disorder that occurs in part because of the selective …

Primary tissue for cellular brain repair in Parkinson's disease: Promise, problems and the potential of biomaterials

N Moriarty, CL Parish, E Dowd - European Journal of …, 2019 - Wiley Online Library
The dopamine precursor, levodopa, remains the “gold standard” treatment for Parkinson's
disease, and, although it provides superlative efficacy in the early stages of the disease, its …

Repairing the brain: cell replacement using stem cell-based technologies

C Henchcliffe, M Parmar - Journal of Parkinson's Disease, 2018 - content.iospress.com
Current approaches to cell replacement therapy in Parkinson's disease are strongly focused
on the dopamine system, with the view that restoring dopaminergic inputs in a localized and …

Micro-and nanotechnology approaches to improve Parkinson's disease therapy

PV Torres-Ortega, L Saludas, AS Hanafy… - Journal of controlled …, 2019 - Elsevier
Current therapies for Parkinson's disease are symptomatic and unable to regenerate the
brain tissue. In recent years, the therapeutic potential of a wide variety of neuroprotective …