Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves
binding ferroportin, the main iron export protein, resulting in its internalization and …

Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis.
Abnormal hepcidin production has emerged as a causative factor in several common iron …

The secreted peptide hormone hepcidin regulates systemic and local iron homeostasis
through degradation of the iron exporter ferroportin. Dysregulation of hepcidin leads to …

Iron is an essential biogenic element for both prokaryotic and eukaryotic cells. In humans
iron is present in hundreds of different metalloproteins. The peptide hormone hepcidin …

The interaction between hepcidin and ferroportin is the key mechanism involved in
regulation of systemic iron homeostasis. This axis can be affected by multiple stimuli …

The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting
degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes …

Inappropriate production of the iron-regulatory hormone hepcidin contributes to the
pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes …

Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is
induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to …

The discovery of hepcidin clarified the basic mechanism of the control of systemic iron
homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by …

The maintenance of stable extracellular and intracellular iron concentrations requires the
coordinated regulation of iron transport into plasma. Iron is a fundamental cofactor for …