Transcriptional regulation is a critical biological process that allows the cell or an organism
to respond to a variety of intra-and extra-cellular signals, to define cell identity during …

Eukaryotic transcriptional regulation requires the integration of complex signals by the
transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications …

Transcription, or the process by which DNA produces RNA, is a central aspect of gene
expression. Transcription factors regulate transcription during development and in disease …

Pioneer transcription factors play a primary role in establishing competence for gene
expression and initiating cellular programming and reprogramming, and their dysregulation …

The control of eukaryotic transcription requires the sequential interaction and precise
coordination of a variety of large enzymatic complexes that are recruited by sequence …

All aspects of transcription and its regulation involve dynamic events. The basal transcription
machinery and regulatory components are dynamically recruited to their target genes, and …

Transcription regulation is critical to organism development and homeostasis. Control of
expression of the 20,000 genes in human cells requires many hundreds of proteins acting …

At the linear DNA level, gene activity is believed to be driven by binding of transcription
factors, which subsequently recruit the RNA polymerase to the gene promoter region …

The spatiotemporally and quantitatively correct activity of a gene requires the presence of
intact coding sequence as well as properly functioning regulatory control. One of the great …

Regulation of eukaryotic gene expression is far more complex than one might have
imagined 30 years ago. However, progress towards understanding gene regulatory …