[PDF][PDF] Natural killer cells: primary target for hepatitis C virus immune evasion strategies?

L Golden‐Mason, HR Rosen - Liver transplantation, 2006 - Wiley Online Library
Liver cirrhosis and hepatocellular carcinoma secondary to chronic hepatitis C virus (HCV)
infection requiring transplantation represents a significant public health problem. The most …

Natural killer cells: multifaceted players with key roles in hepatitis C immunity

L Golden‐Mason, HR Rosen - Immunological reviews, 2013 - Wiley Online Library
Natural killer cells (NK s) are involved in every stage of hepatitis C viral (HCV) infection, from
protection against HCV acquisition and resolution in the acute phase to treatment‐induced …

[HTML][HTML] Natural killer cells in hepatitis C: Current progress

JC Yoon, CM Yang, Y Song, JM Lee - World journal of …, 2016 - ncbi.nlm.nih.gov
Patients infected with the hepatitis C virus (HCV) are characterized by a high incidence of
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …

Cytokine-activated natural killer cells exert direct killing of hepatoma cells harboring hepatitis C virus replicons

J Larkin, A Bost, JI Glass, SL Tan - Journal of interferon & cytokine …, 2006 - liebertpub.com
Hepatitis C virus (HCV)-specific impairments in host immunity have been described at
multiple levels of the innate and adaptive response, which may lead to viral persistence in …

Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells

JC Yoon, JB Lim, JH Park, JM Lee - Journal of virology, 2011 - Am Soc Microbiol
The distinct feature of hepatitis C virus (HCV) infection is a high incidence of chronicity. The
reason for chronic HCV infection has been actively investigated, and impairment of innate …

Immunomodulation of the natural killer cell phenotype and response during HCV infection

GF Njiomegnie, SA Read, N Fewings, J George… - Journal of clinical …, 2020 - mdpi.com
Hepatitis C virus (HCV) infection develops into chronic hepatitis in over two-thirds of acute
infections. While current treatments with direct-acting antivirals (DAAs) achieve HCV …

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis

A Ahmad, F Alvarez - Journal of leukocyte biology, 2004 - academic.oup.com
Natural killer (NK) cells constitute the first line of host defense against invading pathogens.
They usually become activated in an early phase of a viral infection. Liver is particularly …

Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection

S Crotta, M Brazzoli, D Piccioli, NM Valiante… - Journal of hepatology, 2010 - Elsevier
BACKGROUND & AIMS: Hepatitis C virus (HCV) is remarkably successful in establishing
persistent infections due to its ability to evade host immune responses through a …

NK cells, innate immunity and hepatitis C infection after liver transplantation

A Nellore, JA Fishman - Clinical Infectious Diseases, 2011 - academic.oup.com
Liver transplantation in patients with active hepatitis C virus (HCV) infection is followed by
almost universal recurrence of viral infection. The control of HCV infection has been …

Natural killer cells in hepatitis C virus infection: from innate immunity to adaptive immunity

T Takehara, N Hayashi - Clinical Gastroenterology and Hepatology, 2005 - Elsevier
Natural killer (NK) cells are specialized lymphocytes that provide a first line of defense
through their ability to kill pathogen-infected cells and transformed cells. The function of NK …