Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate
function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts …

The incidence of obesity is increasing at an alarming rate and this worldwide epidemic
represents a significant decrease in life span and quality of life of a large part of the affected …

'Hunger is the best spice'is an old and wise saying that acknowledges the fact that almost
any food tastes better when we are hungry. The neurobiological underpinnings of this lore …

The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic
signal. Not only is ghrelin recognized as playing an important role in feeding circuits …

The peptide hormone ghrelin is important for both homeostatic and hedonic eating
behaviors, and its orexigenic actions occur mainly via binding to the only known ghrelin …

Obesity has reached global epidemic proportions and creating an urgent need to
understand mechanisms underlying excessive and uncontrolled food intake. Ghrelin, the …

The gut hormone and neuropeptide ghrelin was initially identified in the periphery as a
compound released in the bloodstream in response to a negative energetic status. In the …

Almost all circulating gut peptides contribute to the control of food intake by signalling
satiety. One important exception is ghrelin, the only orexigenic peptide hormone thus far …

The prevalence of obesity continues to increase and has reached epidemic proportions.
Accumulating data over the past few decades have given us key insights and broadened our …

Ghrelin, a circulating orexigenic stomach-derived hormone, has recently been implicated in
extra-homeostatic feeding, increasing food reward and food-motivated behavior. The …