Background: Children with chronic kidney disease (CKD) are at risk for impaired
neurocognitive functioning. We investigated metabolomic associations with neurocognition …

Background Untargeted plasma metabolomic profiling combined with machine learning
(ML) may lead to discovery of metabolic profiles that inform our understanding of pediatric …

Metabolomic studies, employing sophisticated analytical chemistry and statistical methods to
systematically study the collection of small molecules (typically, 1500 Daltons; eg., sugars …

Methods The Chronic Kidney Disease in Children (CKiD) study is a multi-institutional,
prospective cohort that enrolled children aged six-months to 16-years with estimated …

Metabolomic Patterns in Adolescents With Mild to Moderate CKD - Kidney International Reports
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Metabolomics is defined as the quantification of small molecules (usually, 1500 Daltons)
within a biologic specimen (eg, plasma)(1). Detectable metabolites belong to various …

Results Baseline characteristics were 391 (61%) male; median age 12 years; median eGFR
54 ml/min per 1.73 m 2; 448 (69%) nonglomerular diagnosis. Over a median follow-up of 4.8 …

BACKGROUND Metabolomic profiling in individuals with chronic kidney disease (CKD) has
the potential to identify novel biomarkers and provide insight into disease pathogenesis …

Background Chronic kidney disease is strongly linked to neurocognitive deficits in adults
and children, but the pathophysiologic processes leading to these deficits remain poorly …

In North America, children younger than 20 years of age account for less than 2% of the total
chronic kidney disease (CKD) patient population; however, the prevalence of pediatric CKD …