The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

H Schneider, E Berger, B Dolan… - Biochemical …, 2019 - portlandpress.com
Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush
border membrane of small intestinal enterocytes and presents an extended O-glycosylated …

The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small …

EK Malmberg, T Pelaseyed, ÅC Petersson… - Biochemical …, 2008 - portlandpress.com
The membrane-bound mucins have a heavily O-glycosylated extracellular domain, a single-
pass membrane domain and a short cytoplasmic tail. Three of the membrane-bound mucins …

Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity

S Resta-Lenert, S Das, SK Batra… - American Journal of …, 2011 - journals.physiology.org
The membrane-bound mucin MUC17 (mouse homolog Muc3) is highly expressed on the
apical surface of intestinal epithelia and is thought to play a role in epithelial restitution and …

Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis

Y Luu, W Junker, S Rachagani, S Das, SK Batra… - The international journal …, 2010 - Elsevier
The membrane-bound mucins, MUC17 (human) and Muc3 (mouse), are highly expressed
on the apical surface of intestinal epithelia and are thought to be cytoprotective. The …

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C

C Segui-Perez, DAC Stapels, Z Ma, J Su… - Journal of Cell …, 2024 - journals.biologists.com
Glycosylated mucin proteins contribute to the essential barrier function of the intestinal
epithelium. The transmembrane mucin MUC13 is an abundant intestinal glycoprotein with …

Stuck to MUC2

C Van Ooij - Nature Reviews Microbiology, 2010 - nature.com
Stuck to MUC2 | Nature Reviews Microbiology Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3

IA Khatri, R Wang, JF Forstner - Biochemical Journal, 2004 - portlandpress.com
Rat intestinal mucin Muc3 (rMuc3), like its human homologue (MUC3) and several other
membrane mucins, contains a C-terminally located SEA (sea urchin sperm protein …

The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation

P Dhar, J McAuley - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
The family of cell surface (cs-) mucins are constitutively expressed at the cell surface by
nearly all epithelial cells, beneath the gel-mucin layer. All cs-mucin family members have …

Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon

S Senapati, SB Ho, P Sharma, S Das… - Journal of clinical …, 2010 - jcp.bmj.com
Aim To determine the cellular location and expression of MUC17 mucin in specimens of
normal, inflamed and neoplastic colon. Methods Immunohistochemical analysis of human …

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

YH Sheng, R Lourie, SK Lindén, PL Jeffery, D Roche… - Gut, 2011 - gut.bmj.com
Background and Aims The MUC13 transmembrane mucin is highly and constitutively
expressed in the small and large intestine. Although MUC13 polymorphisms have been …