Enhancement of phenotypic instability by α-difluoro-methylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions

MA Moore, H Tsuda, T Ogiso, Y Mera, N Ito - Cancer letters, 1984 - Elsevier
The effects of α-difluoromethylornithine (DFMO), butylated hydroxyanisole (BHA), sodium
phenobarbital (PB) and 2-acetylaminofluorene (AAF) administration on the further …

Importance of the duration of inhibition on intestinal carcinogenesis by difluoromethylornithine in rats

ND Nigro, AW Bull, ME Boyd - Cancer letters, 1987 - Elsevier
The effect of the duration and sequence of inhibition of intestinal tumor formation in rats was
studied to determine whether part time inhibition has any value. Four groups of male …

Modification of the development of N-nitrosomorpholine-induced hepatic lesions by 2-acetylaminofluorene, phenobarbital and 4, 4′-diaminodiphenylmethane: a …

N Ito, MA Moore, P Bannasch - Carcinogenesis, 1984 - academic.oup.com
Abstract The effects of 2-acetylaminofluorene (2-AAF), sodium phenobarbital (PB) and 4, 4′-
diaminodiphenylmethane (DDPM) on the developmental sequence of N-nitrosomorpholine …

Short term induction of preneoplastic nodules in the rat liver. I. The role of 2-AAF as selecting agent

CA Van der Heijden, J Dormans… - European Journal of …, 1980 - Elsevier
Induction of preneoplastic nodules by a single administration of N-nitrosodiethylamine
(NDEA) as initiator and selective stimulation of proliferation by 2-acetylaminofluorene (2 …

Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats

D Tiwawech, R Hasegawa, Y Kurata… - …, 1991 - academic.oup.com
Dose-dependent development of pre-neoplastk liver cell foci induced by 2-
acetylaminofluorene (2-AAF) was investigated in relation to cell-proliferative activity. Male …

Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation

P Gerlyng, T Grotmol, PO Seglen - Carcinogenesis, 1994 - academic.oup.com
The complete liver carcinogen 2-acetylaminofluorene (2-AAF) promoted the outgrowth of
large neoplastic liver nodules and hepatocellular carcinomas in diethylnitrosamine-treated …

Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital

TD Pugh, S Goldfarb - Cancer Research, 1978 - AACR
Combined histochemical and autoradiographic techniques with serial cryostat sections have
been developed for determining the number, type, and nuclear labeling indices after in vivo …

Nucleolar organizer regions in hepatocarcinogenesis induced by N‐2‐fluorenylacetamide in rats: comparison with bromodeoxyuridine immunohistochemistry

T Tanaka, T Takeuchi, A Nishikawa… - Japanese journal of …, 1989 - Wiley Online Library
The number of silver‐stained nucleolar proteins (AgNOR) was counted in preneoplastic and
neoplastic rat liver lesions induced by N‐2‐fluorenylacetamide (FAA) and was compared …

Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their …

P Greaves, E Irisarri, AM Monro - Journal of the National Cancer …, 1986 - academic.oup.com
The histologic appearance and cytochemical characteristics of foci of hepatic cellular
alteration, hepatic nodules, and hepatocellular carcinomas occurring in male Sprague …

Effects of α-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors …

J Bartholeyns, J Koch-Weser - Cancer Research, 1981 - AACR
The effects of α-difluoromethylornithine (DFMO; RMI 71782) in combination with vindesine
or Adriamycin were investigated in three different animal tumor models. When given in a …