Pulmonary hyperinflation impairs the function of the diaphragm in patients with chronic
obstructive pulmonary disease (COPD). However, it has been recently demonstrated that the …

Background In patients with severe chronic obstructive pulmonary disease, the diaphragm
undergoes physiologic adaptations characterized by an increase in energy expenditure and …

Inspiratory muscle weakness in patients with chronic obstructive pulmonary disease (COPD)
is of major clinical relevance; maximum inspiratory pressure generation is an independent …

Background. In patients with chronic obstructive pulmonary disease (COPD) and
hyperinflation of the lungs, dysfunction of the diaphragm may contribute to respiratory …

Respiratory muscles are essential to alveolar ventilation. These muscles work against
increased mechanical loads due to airflow limitation and geometrical changes of the thorax …

Inspiratory muscle weakness in patients with COPD is of major clinical relevance. For
instance, maximum inspiratory pressure generation is an independent determinant of …

The function of the respiratory muscles is affected profoundly by the presence of chronic
obstructive pulmonary disease (COPD) because of the increase in the work of breathing and …

The pathophysiological mechanisms of weaning from mechanical ventilation are not fully
known, but there is accumulating evidence that mechanical ventilation induces inspiratory …

The diaphragm and other respiratory muscles undergo extensive remodeling in both animal
models of emphysema and in human chronic obstructive pulmonary disease, but the nature …

In striated muscle, chronic increases in workload result in changes in myosin phenotype.
The aim of this study was to determine whether such changes occur in the diaphragm of …