Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's …

Q Zheng, H Liu, H Zhang, Y Han, J Yuan… - Advanced …, 2023 - Wiley Online Library
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's
disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting …

Mitochondria‐targeted nanoparticles in treatment of neurodegenerative diseases

Y Zhang, H Yang, D Wei, X Zhang, J Wang, X Wu… - …, 2021 - Wiley Online Library
Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

Nanotechnology-based drug delivery strategies to repair the mitochondrial function in neuroinflammatory and neurodegenerative diseases

LF González, LE Bevilacqua, R Naves - Pharmaceutics, 2021 - mdpi.com
Mitochondria are vital organelles in eukaryotic cells that control diverse physiological
processes related to energy production, calcium homeostasis, the generation of reactive …

Mitochondria: a therapeutic target for Parkinson's disease?

Y Luo, A Hoffer, B Hoffer, X Qi - International journal of molecular sciences, 2015 - mdpi.com
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The
exact causes of neuronal damage are unknown, but mounting evidence indicates that …

Emerging concepts of mitochondrial dysfunction in Parkinson's disease progression: Pathogenic and therapeutic implications

L Rani, AC Mondal - Mitochondrion, 2020 - Elsevier
Mitochondria are very dynamic organelle which plays a multifactorial role for a broad range
of physiological processes inside the cell to maintain neural circuit integrity. They are …

Single-Atom Nanocatalytic Therapy for Suppression of Neuroinflammation by Inducing Autophagy of Abnormal Mitochondria

B Li, Y Bai, C Yion, H Wang, X Su, G Feng, M Guo… - ACS …, 2023 - ACS Publications
Catalysts have achieved efficacy in scavenging reactive oxygen species (ROS) to eliminate
neuroinflammation, but it ignores the essential fact of blocking the source of ROS …

Nano‐Brake Halts Mitochondrial Dysfunction Cascade to Alleviate Neuropathology and Rescue Alzheimer's Cognitive Deficits

Q Zhang, Q Song, R Yu, A Wang, G Jiang… - Advanced …, 2023 - Wiley Online Library
Mitochondrial dysfunction has been recognized as the key pathogenesis of most
neurodegenerative diseases including Alzheimer's disease (AD). The dysregulation of …

Facilitating pro-survival mitophagy for alleviating Parkinson's disease via sequence-targeted lycopene nanodots

X Xia, H Li, X Xu, G Zhao, M Du - ACS nano, 2023 - ACS Publications
The pathogenesis of Parkinson's disease is closely linked to impaired mitochondrial function
and abnormal mitophagy. Biocompatible natural antioxidants effectively protect …

Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice

C Gao, Y Wang, J Sun, Y Han, W Gong, Y Li, Y Feng… - Acta Biomaterialia, 2020 - Elsevier
Biomimetic nanotechnology represents a promising approach for the delivery of therapeutic
agents for the treatment of complex diseases. Recently, neuronal mitochondria have been …

Mitochondrial dysfunction and Parkinson's disease: pathogenesis and therapeutic strategies

S Moradi Vastegani, A Nasrolahi, S Ghaderi… - Neurochemical …, 2023 - Springer
Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …