Efforts to understand our anatomy and physiology can involve four often overlapping
phases. We study what occurs, then how, then ask why, and then seek clinical applications …

In a 1960 paradigm of skeletal physiology, effector cells (chondroblasts, fibroblasts,
osteoblasts, osteoclasts, etc.) regulated by nonmechanical agents wholly determined the …

The view that nonmechanical agents dominate control of osteoblasts and osteoclasts and
thus postnatal changes in bone strength and mass (agent¡ effector cells¡ disease) is …

According to the Utah paradigm of skeletal physiology:(1) mechanical forces on skeletons
generate signals in skeletal organs that control the biologic mechanisms that determine the …

Bone tissue forms and is remodeled in response to the mechanical forces that it
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …

Our knowledge of physiology and our ability to control it for medical needs advance in steps
that one should evaluate in the context of when they happened. In 1890 it could have taken …

The still-evolving Utah paradigm of skeletal physiology supplements former ideas about the
control of postnatal bone strength and" mass" in health and disease, on earth and in orbit …

Bone is a complex, hierarchically organized organ system whose composition and structure
are closely related to, and in many ways controlled by, the functional demands made upon it …

Bone is often thought of as being a passive, inactive tissue like a skeleton hanging in the
anatomy lab. Often, bone tissue is envisioned statically in terms of two dimensions similar to …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …