Sex and gender differences in lung cancer and chronic obstructive lung disease

JM Siegfried - Endocrinology, 2022 - academic.oup.com
Two highly prevalent pulmonary diseases, lung cancer and chronic obstructive lung disease
(COPD), show both sex and gender differences in their presentations and outcomes. Sex …

Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor α and β and show biological responses to estrogen

LP Stabile, ALG Davis, CT Gubish, TM Hopkins… - Cancer research, 2002 - AACR
Lung cancer is becoming increasingly common in women and in the United States accounts
for more female cancer deaths annually than breast cancer. Many epidemiological studies …

Smoking out reproductive hormone actions in lung cancer

JM Siegfried - Molecular Cancer Research, 2014 - AACR
Experimental and population-based evidence has been steadily accumulating that steroid
hormones are fundamentally involved in the biology of the lung. Both estrogen and …

Lung cancer in women: role of estrogens

S Chakraborty, AK Ganti, A Marr… - Expert review of …, 2010 - Taylor & Francis
The incidence of lung cancer in females is increasing, in contrast to that seen in males. In
addition, the proportion of lung cancer cases in women attributable to smoking is …

Estrogen signaling in lung cancer: an opportunity for novel therapy

CS Baik, KD Eaton - Cancers, 2012 - mdpi.com
Lung cancer is the leading cause of cancer death in US and represents a major public
health burden. Epidemiologic data have suggested that lung cancer in women may possess …

[HTML][HTML] It's all about sex: male-female differences in lung development and disease

MA Carey, JW Card, JW Voltz, SJ Arbes Jr… - … in endocrinology and …, 2007 - ncbi.nlm.nih.gov
Accumulating evidence suggests that gender impacts the incidence, susceptibility and
severity of several lung diseases. Gender also influences lung development and physiology …

Estrogen receptor signaling in lung cancer

JM Siegfried, PA Hershberger, LP Stabile - Seminars in oncology, 2009 - Elsevier
Lung cancer has long been thought of as a cancer that mainly affects men, but over the past
several decades, because of the high increase in tobacco use by women, there has been a …

It's all about sex: gender, lung development and lung disease

MA Carey, JW Card, JW Voltz, SJ Arbes… - Trends in Endocrinology …, 2007 - cell.com
Accumulating evidence suggests that gender affects the incidence, susceptibility and
severity of several lung diseases. Gender also influences lung development and physiology …

Activity and intracellular location of estrogen receptors α and β in human bronchial epithelial cells

MM Ivanova, W Mazhawidza, SM Dougherty… - Molecular and cellular …, 2009 - Elsevier
Gender differences in lung disease and cancer are well-established. We reported estrogenic
transcriptional responses in lung adenocarcinoma cells from females but not males despite …

Sex differences in estrogen receptor subcellular location and activity in lung adenocarcinoma cells

MM Ivanova, W Mazhawidza… - American journal of …, 2010 - atsjournals.org
The role of estrogens in the increased risk of lung adenocarcinoma in women remains
uncertain. We reported that lung adenocarcinoma cell lines from female, but not male …