Compounds with a chalcone scaffold-based structure have demonstrated promising
anticancer biological activity. However, the molecular interactions between chalcone …

Non-small cell lung cancer (NSCLC) is a common pathological type of lung cancer, which
has a serious impact on human life, health, psychology and life. At present, chemotherapy …

Lung cancer is a pervasive and challenging disease with limited treatment options, with
global health challenges often present with complex molecular profiles necessitating the …

Epidermal growth factor receptor (EGFR) is a prominent target for anticancer therapy due to
its role in activating several cell signaling cascades. Clinically approved EGFR inhibitors are …

This study aimed to explore the main active ingredients and potential targets of Solanum
nigrum (SN), so as to reveal the potential molecular mechanism of SN in the treatment of …

During the last decade, Salinosporamide A (SSAA) isolated by Salinispora tropica, or
Salinispora arenicola known as the p26 proteasome inhibitor (anticancer agent) led to a …

Noscapine, an opium alkaloid, was discovered to bind tubulin, arrest dividing cells at
mitosis, and selectively induce apoptosis to cancer cells. N‐3‐Br‐Benzyl‐Noscapine (Br‐Bn …

Background SiNiSan (SNS) is an ancient traditional Chinese medicine (TCM) used to treat
liver and spleen deficiencies. We studied the unique advantages of using SNS to treat …

Homoharringtonine (HHT), an Food and Drug Administration (FDA)-approved anti-leukemia
drug, exerts anti-tumor activity in several solid tumors, including colorectal cancer (CRC) …

The past years have witnessed the versatile applications of interaction fingerprint method,
including three-dimensional structure analysis, docking-pose clustering and filtering, scoring …