Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient
pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the …

Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large
interpatient variability, partly due to genetic variations in the gene encoding cytochrome …

Introduction: Phenytoin, a widely prescribed old-generation antiepileptic drug, requires
careful individualization of dosage to compensate for its prominent pharmacokinetic …

To develop a pre‐emptive genetic test that comprises multiple predisposing alleles for the
prevention of phenytoin‐related severe cutaneous adverse reactions (SCARs), three sets of …

Drug treatment of epilepsy is characterized by unpredictability of efficacy, adverse drug
reactions, and optimal doses in individual patients, which, at least in part, is a consequence …

Human leukocyte antigen B (HLA‐B) is a gene that encodes a cell surface protein involved
in presenting antigens to the immune system. The variant allele HLA‐B* 15: 02 is associated …

Phenytoin and carbamazepine are effective and inexpensive anti-epileptic drugs (AEDs). As
with many AEDs, a broad range of doses is used, with the final “maintenance” dose normally …

To search for the optimal dosage of phenytoin in patients with epilepsy based on the
metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients …

Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

Objective: Asians who carry the HLA-B* 1502 allele have an elevated risk of developing
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with …