Trehalose-6-phosphate synthase (TPS1) was identified as a virulence factor for
Cryptococcus neoformans and a promising therapeutic target. This study reveals previously …

The trehalose pathway is essential for stress tolerance and virulence in fungi. We
investigated the importance of this pathway for virulence of the pathogenic yeast …

The disaccharide trehalose has been found to play diverse roles, from energy source to
stress protectant, and this sugar is found in organisms as diverse as bacteria, fungi, plants …

Invasive fungal diseases are a major threat to human health, resulting in more than 1.5
million deaths worldwide each year. Yet the arsenal of antifungal therapeutics remains …

Nutrient acquisition and sensing are critical aspects of microbial pathogenesis. Previous
transcriptional profiling indicated that the fungal pathogen Cryptococcus neoformans, which …

Cryptococcus gattii is a resurgent fungal pathogen that primarily infects immunocompetent
hosts. Thus, it poses an increasingly significant impact on global public health; however, the …

Among pathogenic environmental fungi, spores are thought to be infectious particles that
germinate in the host to cause disease. The meningoencephalitis-causing yeast …

Invasive fungal diseases are a major threat to human health, resulting in more than 1.5
million annual deaths worldwide. The arsenal of antifungal therapeutics remains limited and …

Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal
infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic …

Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of fungal-
infection-related fatalities, especially in immunocompromised hosts. Several virulence …