Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …

Primary lymphedema is caused by developmental and functional defects of the lymphatic
vascular system that result in accumulation of protein-rich fluid in tissues, resulting in edema …

Angiopoietin (Ang) signaling plays a role in angiogenesis and remodeling of blood vessels
through the receptor tyrosine kinase Tie2, which is expressed on blood vessel endothelial …

Abstract Angiopoietin 1 (Ang1), a ligand for the receptor tyrosine kinase Tie2, regulates the
formation and stabilization of the blood vessel network during embryogenesis. In adults …

Background Dysfunctional lymphatic vessel formation has been implicated in a number of
pathological conditions including cancer metastasis, lymphedema, and impaired wound …

Objective—Angiogenesis and lymphangiogenesis are complex phenomena that involve the
interplay of several growth factors and receptors. Recently, we have demonstrated that in …

Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting
lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial …

Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an
immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not …

The endothelial cell is the essential cell type forming the inner layer of the vasculature. Two
families of receptor tyrosine kinases (RTKs) are almost completely endothelial cell specific …

Objectives—Vascular endothelial growth factor receptor 3 (VEGFR3) plays important roles
both in lymphangiogenesis and angiogenesis. On stimulation by its ligand VEGF-C …