Complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) belong to the family of
beta2 integrins and are expressed mainly by myeloid cell types in humans. Previously, we …

CR3 and CR4, the leukocyte specific β2-integrins, involved in cellular adherence, migration
and phagocytosis, are often assumed to have similar functions. Previously however, we …

Integrin-mediated adhesion of human monocytes to fibrinogen regulated by CD11b/CD18
and the closely related integrin CD11c/CD18, play a key role in inflammation. Peripheral …

Dendritic cells (DCs) play a decisive role in immunity; they interact with various pathogens
via several pattern recognition and different opsonophagocytotic receptors, including Fc-and …

CR3 and CR4 belong to the family of β 2-integrins and play an important role in
phagocytosis, cellular adherence and migration. CR3 and CR4 are generally expected to …

CR3 (CD11b/CD18), a β2 integrin, has a key role in innate antimicrobial defenses, as
evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the …

CD11c/CD18 (α X β 2, p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-
enriched integrin that has been reported to bind to a variety of ligands. These include cell …

CD11c, a member of the leukointegrin family, is expressed prominently on tissue
macrophages and dendritic cells and binds to complement fragment (iC3b), provisional …

During inflammation, cell surface adhesion molecules guide the adhesion and migration of
circulating leukocytes across the endothelial cells lining the blood vessels to access the site …

Abstract CR3 (CD11b/CD18; αmβ2 integrin) is a conserved phagocytic receptor. The active
conformation of CR3 binds the iC3b fragment of complement C3 as well as many host and …