Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Cellular senescence constitutes a stress response mechanism in reaction to a plethora of
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

Here, we provide an overview of the importance of cellular fate in cancer as a group of
diseases of abnormal cell growth. Tumor development and progression is a highly dynamic …

For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cellular senescence is a key component of human aging that can be induced by a range of
stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of …

Damaged cells at risk of neoplastic transformation can be neutralized by apoptosis or
engagement of the senescence program, which induces permanent cell-cycle arrest and a …