Standards and methodological rigor in pulmonary arterial hypertension preclinical and translational research

S Provencher, SL Archer, FD Ramirez… - Circulation …, 2018 - Am Heart Assoc
Despite advances in our understanding of the pathophysiology and the management of
pulmonary arterial hypertension (PAH), significant therapeutic gaps remain for this …

Translating research into improved patient care in pulmonary arterial hypertension

S Bonnet, S Provencher, C Guignabert… - American journal of …, 2017 - atsjournals.org
We have witnessed significant advances in the management of pulmonary arterial
hypertension (PAH)(1), a rare and severe condition characterized by intense pulmonary …

Pulmonary arterial hypertension: challenges in translational research and a vision for change

G Sutendra, ED Michelakis - Science translational medicine, 2013 - science.org
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with a relentless
course toward heart failure and early death. Existing PAH therapies, all of which were …

Clinical trial design and new therapies for pulmonary arterial hypertension

O Sitbon, M Gomberg-Maitland… - European …, 2019 - Eur Respiratory Soc
Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on
case reports and small series, and was largely ineffectual. As a deeper understanding of the …

Pulmonary arterial hypertension: pathophysiology and treatment

NSH Lan, BD Massam, SS Kulkarni, CC Lang - Diseases, 2018 - mdpi.com
Pulmonary arterial hypertension (PAH), the first category of pulmonary hypertension, is a
chronic and progressive disorder characterised by angioproliferative vasculopathy in the …

Emerging therapies and future directions in pulmonary arterial hypertension

V Gurtu, ED Michelakis - Canadian Journal of Cardiology, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a complex obliterative vascular disease. It remains
deadly despite an explosion of basic research over the past 20 years that identified myriads …

New trial designs and potential therapies for pulmonary artery hypertension

M Gomberg-Maitland, TM Bull, R Saggar… - Journal of the American …, 2013 - jacc.org
A greater understanding of the epidemiology, pathogenesis, and pathophysiology of
pulmonary artery hypertension (PAH) has led to significant advances, but the disease …

Advances in the management of pulmonary arterial hypertension

H Deshwal, T Weinstein… - Journal of Investigative …, 2021 - journals.sagepub.com
The management of pulmonary arterial hypertension (PAH) has significantly evolved over
the last decades in the wake of more sensitive diagnostics and specialized clinical programs …

Management of pulmonary arterial hypertension

JD Mayeux, IZ Pan, J Dechand, JA Jacobs… - Current cardiovascular …, 2021 - Springer
Abstract Purpose of Review This review focuses on the therapeutic management and
individualized approach to Group 1 pulmonary arterial hypertension (PAH), utilizing Food …

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

SL Archer, EK Weir, MR Wilkins - Circulation, 2010 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial
obstruction increases pulmonary vascular resistance, which leads to right ventricular (RV) …