Numerous multiple malformation syndromes associated with pathologic overgrowth have
been described and, for many, their molecular bases elucidated. This review describes the …

Lateralized overgrowth (LO), or segmental overgrowth, is defined as an increase in growth
of tissue (bone, muscle, connective tissue, vasculature, etc.) in any region of the body. Some …

Although problems in overgrowth were documented and appreciated in the nineteenth
century, conditions such as Beckwith–Wiedemannsyndrome (BWS, OMIM 130650) and …

Somatic variants have been well described in tumorigenesis; however, they are only
recently appreciated in other human disorders, such as mosaic overgrowth syndromes …

The phosphatidylinositol‐3‐kinase (PI3K)/AKT/mTOR signaling pathway plays an essential
role in regulation of normal cell growth, metabolism, and survival. Somatic activating …

Overgrowth syndromes (OGS) comprise a heterogeneous group of disorders in which the
main characteristic is that either weight, height, or head circumference is 2–3 standard …

The overgrowth syndromes are important to diagnose, not just for accurate genetic
counseling, but also for knowledge surrounding cancer surveillance and prognosis. There …

Congenital malformations or complex malformation syndromes are frequently associated
with growth failure and have been the subject of much research and discussion in the …

Overgrowth syndromes are a heterogeneous group of rare disorders characterized by
generalized or segmental excessive growth commonly associated with additional features …

Overgrowth syndromes comprise a heterogeneous group of diseases that are characterized
by excessive tissue development. Some of these syndromes may be associated with …