Chronic kidney disease (CKD) is defined as an alteration of kidney structure and/or function
lasting for> 3 months. CKD affects 10% of the general adult population and is responsible for …

Hypoxia is an inherent pathophysiological characteristic of chronic kidney disease (CKD),
which is closely associated with the development of renal inflammation and fibrosis, as well …

HIF plays a crucial role in the pathophysiology of CKD. The underlying molecular
mechanisms, including epigenetics, have been thoroughly investigated. On the basis of the …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

It is generally accepted that renal hypoxia plays an important role in the progression of
chronic kidney disease (CKD). This review focuses on renal hypoxia and hypoxia-inducible …

Role of hypoxia in the pathogenesis of renal disease The kidney shows a remarkable
discrepancy between blood supply and oxygenation. Despite high blood flow and oxygen …

The role of hypoxia, increased oxygen consumption, and hypox... : Current Opinion in
Nephrology and Hypertension The role of hypoxia, increased oxygen consumption, and …

Background The roles of hypoxia and hypoxia inducible factor (HIF) during chronic kidney
disease (CKD) are much debated. Interventional studies with HIF-α activation in rodents …

Studies over the last two decades have established tubulointerstitial hypoxia as a final
common pathway leading to end-stage kidney disease (ESKD). Chronic kidney disease …

In chronic kidney disease, functional impairment correlates with tubulointerstitial fibrosis
characterised by inflammation, accumulation of extracellular matrix, tubular atrophy and …