Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6 in 1, 2‐dimethylhydrazine‐induced rat …

S Umesalma, G Sudhandiran - Basic & clinical pharmacology & …, 2010 - Wiley Online Library
Dietary polyphenols have been found to possess preventive and therapeutic potential
against several types of cancers. We investigated the effect of ellagic acid on colon cancer …

Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway

S Umesalma, G Sudhandiran - European journal of pharmacology, 2011 - Elsevier
Colon cancer is the third most malignant neoplasm in the world and chemoprevention
through dietary intervention is an emerging option to reduce its mortality. Ellagic acid (EA) a …

Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice

L Gu, W Deng, Y Liu, C Jiang, L Sun, X Sun… - International …, 2014 - Elsevier
Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been
reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the …

Flos lonicerae flavonoids attenuate experimental ulcerative colitis in rats via suppression of NF-κB signaling pathway

D Liu, X Yu, H Sun, W Zhang, G Liu, L Zhu - … -Schmiedeberg's Archives of …, 2020 - Springer
This study sought to isolate active Flos lonicerae flavonoids and evaluate their anti-oxidative
and anti-inflammatory effects as well as investigate the molecular mechanistic action of …

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

MA Rosillo, M Sanchez-Hidalgo, A Cárdeno… - Biochemical …, 2011 - Elsevier
Current epidemiological and experimental studies support a beneficial role of dietary
polyphenols in several gastrointestinal diseases, including inflammatory bowel disease. The …

[HTML][HTML] Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2

AK Pandurangan, SAS Kumar… - Pharmacognosy …, 2014 - ncbi.nlm.nih.gov
Colon cancer (CRC) is a serious health problem through worldwide. Development of novel
drug without side effect for this cancer was crucial. Luteolin (LUT), a bioflavonoid has many …

Chemopreventive efficacy of gallic acid, an antioxidant and anticarcinogenic polyphenol, against 1, 2-dimethyl hydrazine induced rat colon carcinogenesis

JS Giftson, S Jayanthi, N Nalini - Investigational new drugs, 2010 - Springer
Colon cancer is a major cause of morbidity and mortality in developed and developing
countries and its etiology is known to be a combination of hereditary, environmental, dietary …

Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis

M Marín, RM Giner, JL Ríos, MC Recio - Journal of ethnopharmacology, 2013 - Elsevier
Abstract Ethnopharmacological relevance Pomegranate (Punica granatum L.; Lythraceae)
has traditionally been used for the treatment of various inflammatory diseases, including …

Modulatory properties of various natural chemopreventive agents on the activation of NF-κB signaling pathway

WS Jeong, IW Kim, R Hu, ANT Kong - Pharmaceutical research, 2004 - Springer
Purpose. To study and compare effects of selected natural chemopreventive agents on the
transcription activation of nuclear factor-kappa B (NF-κB) in human HT-29 colon cancer …

Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model

K Akagi, M Hirose, T Hoshiya, Y Mizoguchi, N Ito… - Cancer letters, 1995 - Elsevier
Effects of dietary supplementation with the antioxidants ellagic acid, quercetin and vanillin
were examined using a medium term multi-organ carcinogenesis model in rats. Groups of …