[HTML][HTML] Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions
Background Vascular endothelial growth factor (VEGF) is known to be a potent promoter of
angiogenesis under both physiological and pathological conditions. Given its role in …
angiogenesis under both physiological and pathological conditions. Given its role in …
Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
[HTML][HTML] Mechanistic modeling quantifies the influence of tumor growth kinetics on the response to anti-angiogenic treatment
TD Gaddy, Q Wu, AD Arnheim… - PLoS computational …, 2017 - journals.plos.org
Tumors exploit angiogenesis, the formation of new blood vessels from pre-existing
vasculature, in order to obtain nutrients required for continued growth and proliferation …
vasculature, in order to obtain nutrients required for continued growth and proliferation …
[HTML][HTML] A two-compartment model of VEGF distribution in the mouse
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …
new microvessels from existing microvasculature. Angiogenesis is a complex process …
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
JS Rudge, J Holash, D Hylton… - Proceedings of the …, 2007 - National Acad Sciences
VEGF is the best characterized mediator of tumor angiogenesis. Anti-VEGF agents have
recently demonstrated impressive efficacy in human cancer trials, but the optimal dosing of …
recently demonstrated impressive efficacy in human cancer trials, but the optimal dosing of …
Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport
FTH Wu, MO Stefanini, F Mac Gabhann… - Physiological …, 2009 - journals.physiology.org
Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …
[HTML][HTML] The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …
[HTML][HTML] A compartment model of VEGF distribution in blood, healthy and diseased tissues
Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …
Mathematical modeling of cellular cross-talk between endothelial and tumor cells highlights counterintuitive effects of VEGF-targeted therapies
H Jain, T Jackson - Bulletin of mathematical biology, 2018 - Springer
Tumor growth and progression are critically dependent on the establishment of a vascular
support system. This is often accomplished via the expression of pro-angiogenic growth …
support system. This is often accomplished via the expression of pro-angiogenic growth …