Systematic reviews are currently favored methods of evaluating research in order to reach
conclusions regarding medical practice. The need for such reviews is necessitated by the …

Widespread reliance on animal models during preclinical research and toxicity testing
assumes their reasonable predictivity for human outcomes. However, of 20 published …

Background Systematic reviews can serve as a tool in translation of basic life sciences
research from laboratory to human research and healthcare. The extent to which reviews of …

The question of how animal studies should be designed, conducted, and analyzed remains
underexposed in societal debates on animal experimentation. This is not only a scientific but …

Background The pharmaceutical industry is in the midst of a productivity crisis and rates of
translation from bench to bedside are dismal. Patients are being let down by the current …

In research aimed at improving human health care, animal studies still play a crucial role,
despite political and scientific efforts to reduce preclinical experimentation in laboratory …

Background The methodological quality of animal studies is an important factor hampering
the translation of results from animal studies to a clinical setting. Systematic reviews of …

The assumption that animal models are reasonably predictive of human outcomes provides
the basis for their widespread use in toxicity testing and in biomedical research aimed at …

Systematic reviews are an important method to support evidence‐based decisions in
healthcare (research). Although not yet as common as clinical systematic reviews, the …

The scientific literature of laboratory animal research is replete with papers reporting poor
reproducibility of results as well as failure to translate results to clinical trials in humans. This …